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Prediction of a Claudin 18.2 targeted Antibody Drug Conjugate Pharmacokinetics in Cancer Patients Using PBPK Modeling

Cardiac Safety of MMV533, a new An malarial Drug Candidate: Concentration on-QTc Analysis from the First-In-Human​

Developing a mechanistic in vitro-in vivo relationship (IVIVR) for drug A using Physiologically-based pharmacokinetic modeling

Development of a kidney transporter-mediated drug-drug interaction between cimetidine (perpetrator) and ranitidine (substrate) using PBPK modeling

A PBPK model-based drug interaction study to inform the dose selection of a new compound

Translational PK of bevacizumab between monkey and human using PBPK modeling

Prediction of target-mediated PK profile of Bevacizumab in cancer patients using PBPK modeling

Development of a mechanistic absorption model for a monoclonal antibody administered subcutaneously

Prediction of a Claudin 18.2 targeted Antibody Drug Conjugate Pharmacokinetics in Cancer Patients Using PBPK Modeling and Simulation

How to optimize clinical trial outcomes?

Unlocking the power of PBPK prediction

Quality Management System at PhinC

Focus on CDISC by Michaël Boily

Focus on PopPK by Sarah Lezzar

Les publications dans lesquelles l’un de nos scientifiques est impliqué.

26 mars 2024 – Translational Therapeutics

Scientists : Puszkiel, A., Bianconi, G., Pasquiers, B. et al.

28 septembre 2023 – Clin Transl Sci 16(11):2222-2235. doi: 10.1111/cts.13622

Scientists : Jeremy Perrier, Virginie Gualano, Eric Helmer, Florence Namour, Viera Lukacova, Amit Taneja 

14 août 2023 – Pharmaceutics

Scientists : Pasquiers B, Benamara S, Felices M, Ternant D, Declèves X, Puszkiel A. Pharmaceutics.

2023 – Clinical Pharmacokinetics

Scientists : Tarral, A., Hovsepian, L., Duvauchelle, T., Donazzolo, Y., Latreille, M., Felices, M., Gualano, V., Delhomme, S., Valverde Mordt, O., Blesson, S., Voiriot, P., & Strub-Wourgaft, N.

Mars 2021 – Antimicrob Agents Chemother 18;65(4):e02150-19. doi: 10.1128/AAC.02150-19.

Scientists : Isabela Ribeiro, Bethania Blum, Jayme Fernandes, Glaucia Santina 2, Makoto Asada, Michael Everson 4, Edgar Schuck, Ethel Feleder, Eric Evene, Virginie Gualano 

Août 2023 – Investigative Radiology – Volume 57, Issue 8, p 510-516.

Scientists : Jurkiewicz E, Tsvetkova S, Grinberg A, Pasquiers B.

Novembre 2021 – Eur J Clin Pharmacol, 77(11)

Scientists : Hirt D, Oualha M, Pasquiers B, Blanot S, Rubinstazjn R, Glorion C, Messaoudi SE, Drummond D, Lopez V, Toubiana J, Béranger A, Boujaafar S, Zheng Y, Capito C, Winter S, Léger PL, Berthaud R, Gana I, Foissac F, Tréluyer JM, Bouazza N, Benaboud S.

2021 – The AAPS journal, 23(4), 89

Scientists : Szeto, K. X., Le Merdy, M., Dupont, B., Bolger, M. B., & Lukacova, V.

2020 – European Journal of Clinical Pharmacology, 76(10), 1393-1400. doi:10.1007/s00228-020-02929-6

Scientists : Dubourg, J., Perrimond-Dauchy, S., Felices, M., Bolze, S., Voiriot, P., & Fouqueray, P

2020 – British Journal of Clinical Pharmacology, 86(11), 2174-2181. doi:10.1111/bcp.14309

Scientists : Funck‐Brentano, C., Felices, M., Fur, N. L., Dubourdieu, C., Desché, P., Vanhoutte, F., & Voiriot, P.

2018 – J Allergy Clin Immunol Pract, 6(4):1257-1263. doi: 10.1016/j.jaip.2017.09.021.

Scientists : Thierry Duvauchelle, Philippe Robert, Yves Donazzolo, Sabrina Loyau, Bernard Orlandini, Philippe Lehert, Jeanne-Marie Lecomte, Jean-Charles Schwartz 

2014 – Vaccine. 32(46):6138-45. doi: 10.1016/j.vaccine.2014.08.070.

Scientists : Josianne Nitcheu Tefit, Sandrine Crabé, Bernard Orlandini , Haylene Nell , Albert Bendelac , Shenglou Deng , Paul B Savage , Luc Teyton , Vincent Serra 

2008 – J Steroid Biochem Mol Biol, 109(1-2):177-84

Scientists : Raynaud JP, Aumonier C, Gualano V, Betea D, Beckers A.

2007 – Clin. Pharm; Ther., 81(3):401-5,

Scientists : Gregoire N, Hovsepian L, Gualano V, Evène E, Dufour G, Gendron A.

2004 – Clin. Drug. Invest. 24(12): 739-747

Scientists : Chassard D, Geneteau A, Gualano V, Brault M.

2004 – J Clin Pharmacol. 44: 1114-24

Scientists : Grégoire N, Gualano V, Geneteau A, Millerioux L, Brault M, Mignot A, Roze J.C.

2003 – Arzneimittelforschung; 53(3):201-5,

Scientists : Picollo R, Brion N, Gualano V, Millerioux L, Marchetti M, Rosignoli MT, Dionisio P.

2002 – Chemotherapy. 48(3):116-21

Scientists : Mignot A, Guillaume M, Brault M, Gualano V, Millerioux L, Gohler K, Stahlberg HJ.

1999 – Clin. Drug Investig. 17; 6: 475-82

Scientists : Gualano V, Ntssikoussalabongui B, Mignot A, Duvauchelle T, Felices M, Guillaume M, Orlandini B, Holguin J, Alcaïde A.

1998 – Clin. Drug Investigation, 16, 141 –149

Scientists : Duvauchelle T., Millérioux L., Gualano V. Evène E., Alcaïde A.

1996 – J Chromatogr A. 5;729(1-2):309-14

Scientists : Millerioux L, Brault M, Gualano V, Mignot A.

1994 – Nephron. 66(2):157-61

Scientists : Chatelut E, Rostaing L, Gualano V, Vissac T, De Forni M, Ton-That H, Suc JM, Houin G, Canal P

1993 – Bull Cancer 80(5):408-17

Scientists : Forni M, Gualano V, Canal P, Martel P, Izar-Soum F, Chevreau C, Soulie P, Roche H, Bugat R

1993 – Cancer Chemother Pharmacol.; 32(5): 379-84

Scientists : Muller C, Chatelut E, Gualano V, De Forni M, Huguet F, Attal M, Canal P, Laurent G.

1991 – Clin. Neuropharmacol. , 14(5):432-7

Scientists : Montastruc JL, Rascol O, Senard JM, Gualano V, Bagheri H, Houin G, Lees A, Rascol A.

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Scientists : Montastruc JL, Rascol O, Senard JM, Gualano V, Bagheri H, Houin G, Lees A, Rascol A.

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