Internship Offer – PBPK Modeling

Topic: Comparative study of adrenaline routes of administration – PBPK approach

Context

Adrenaline is an essential medicine in the management of severe anaphylactic reactions. It is currently marketed for administration by diverse routes, including intramuscular, subcutaneous, intravenous, and even intranasal (IM, SC, IV, IN). Depending on the route, adrenaline’s pharmacokinetics vary considerably and the available data are scattered.

Physiologically-Based Pharmacokinetic (PBPK) modeling integrates physiological, physicochemical, and pharmacokinetic knowledge in a mechanistic framework to predict a drug’s fate in the body. It is a powerful tool for extrapolating across species, administration routes, and populations—especially when clinical data are limited.

This internship will first aim to consolidate the existing literature on adrenaline PK for the various routes of administration. Subsequently, a PBPK model will be developed to quantitatively compare exposure profiles by route (e.g., onset of action, bioavailability, relevance in different populations) and to identify the key limitations to accurately simulating each profile.

Internship goals

• Literature review on adrenaline pharmacokinetics: pre-clinical and clinical data across the different administration routes.
• Data structuring: extraction of key parameters, database creation, identification of uncertainties.
• Development of a pre-clinical and/or clinical PBPK model for adrenaline using GastroPlus (or another platform).
• Comparison of simulated PK profiles by administration route and critical analysis of the results.
• Reflection on the implications for modeling strategy and the development of new delivery devices.

Profile Sought

• Pharmacy student, M2 student, or engineering-school student specializing in pharmacokinetics, modeling, public health, or pharmaceutical sciences.
• Basic knowledge of pharmacokinetics (absorption, distribution, metabolism, elimination) desired.
• Initial experience with PBPK modeling tools (GastroPlus, PK-Sim, Simcyp, …) is a plus.
• Curiosity, scientific rigor, and critical thinking.
• Comfortable reading scientific literature in English.

Supervision & Environment

The intern will join the PBPK team in our Massy (91) office and be mentored by an experienced scientist, receiving methodological and technical support throughout the internship.

PhinC Development is a consulting firm specialized in Model-Informed Drug Development (MIDD). We help biotech companies and pharmaceutical firms maximize the value of their data through pharmacokinetic modeling (PK-NCA, PK/PD, PBPK, ECG…). With offices in Massy and Montréal, we contribute to projects ranging from pre-clinical phases to phase 3.

Candidature : CV + quelques lignes de motivation à envoyer à corentin.mit@phinc.fr