Expert in Physiologically-Based Pharmacokinetic (PBPK) Modeling

Job description

PhinC Development is looking for an expert in Physiologically-Based Pharmacokinetic (PBPK) modeling to strengthen its modeling team.

The selected candidate will play a central role in the development, validation, and application of PBPK models to support drug development strategies. These include first-in-human dose prediction, formulation optimization, drug-drug interactions, specific populations, and regulatory submissions.

This position offers the opportunity to collaborate closely with recognized experts in Model-Informed Drug Development (MIDD) within a dynamic and agile biotech-oriented environment.

Main Responsibilities

• Develop, validate, and apply PBPK models based on preclinical and clinical data (in silico / in vitro / in vivo).
• Contribute to the design of modeling strategies in support of (pre)clinical development goals (translation, dose selection, formulation, DDI, pediatrics, special populations, etc.).
• Provide robust quantitative analyses and simulations to support regulatory submissions and interactions with health authorities.
• Collaborate closely with multidisciplinary teams: pharmacologists, clinicians, statisticians, CMC experts, etc.
• Write and review scientific reports, client deliverables, regulatory dossiers, and publications.

Profile Sought

• PhD or Master’s degree in pharmacokinetics, pharmacology, pharmaceutical sciences, or a related field.
• Proven experience (≥3 years) in PBPK modeling, ideally in an industry, CRO, or applied academic setting
• Proficiency in GastroPlus is required. Experience with other commercial or open-source platforms (Simcyp, PK-Sim, etc.) is a plus.
• Experience in developing (pre)clinical models for small molecules (and biologics, optionally) for regulatory purposes is a plus.
• Strong ability to integrate heterogeneous data (in vitro, preclinical, clinical) within a mechanistic framework.
• Scientific rigor, autonomy, team spirit, and strong writing skills.
• Previous interactions with regulatory agencies (EMA/FDA) are an asset.
• Fluency in scientific English (written and spoken) is essential.

What We Offer

• Attractive compensation package including profit-sharing and performance bonuses.
• Participation in scientific conferences (ASCPT, PAGE, Simulations Plus Workshops…).
• A stimulating environment working with innovative and diverse biotech companies.
• A human-sized team with opportunities for rapid growth and increased responsibilities.
• Mentorship for young scientists and a collaborative work atmosphere.
• Partial remote work possible.

Who We Are

PhinC Development is a scientific consulting company specialized in model-informed drug development. With expertise in PK/PD, PBPK, biostatistics, and regulatory strategy, our approach is built on:

• Data Deep Learning: maximizing the value of all available data to support robust simulations and predictions.
• Biotech Agility: adaptability, client proximity, and a culture of fast impact.
• Product Development Expertise: our models are always designed as decision-making tools.

Based in Massy (Greater Paris area), with a subsidiary in Montreal (Canada), PhinC collaborates with partners around the globe.