Population PK Expert, PK/PD Pharmacometrician

PhinC Development has an opening position for an expert pharmacometrician specializing in population pharmacokinetics modeling. The candidate will play a key role in developing and applying population PK/PD models to support dose selection, regulatory submissions, and clinical trial design, and will be supported by expert scientists with strong experience in MIDD.

Key Responsibilities:

• Evaluate appropriate methodology, develop, validate, and apply population PK/PD models to characterize drug pharmacokinetics and pharmacodynamics throughout the development of treatment candidates in various patient populations
• Support sponsors/clients with model-based tools and quantitative solutions to support their development strategy, strengthen dose selection rationales, optimize study design, and support their regulatory strategy (e.g., special populations, PIPs)
• Collaborate with cross-functional teams, including clinical pharmacologists, statisticians, datamanager, and regulatory specialists.
• Contribute to the development of modeling and simulation strategies for project teams.
  Author and review technical reports, regulatory documents, and scientific publications.

Qualifications:

• PhD or Master’s degree in Population Pharmacokinetics, Pharmacology, Pharmaceutical Sciences, or a related field.
• At least 2 years of relevant experience in population PK/PD modeling in an industry or academic setting.
• Expertise in modeling tools such as NONMEM, Monolix and strong programming skills in R or SAS, or similar platforms for data analysis and visualization.
• Experience in authoring regulatory submissions and interacting with health authorities is a plus.

You are fluent in English both orally and written, have good communication and presentation skills, scientific rigor and motivation and strong organization skills.

What we offer:

• An attractive compensation package including profit-sharing and participation bonuses
• Participate at international conferences
• Responsability and autonomy
• Opportunity for mentorship for young scientists.

The company is located in the Paris region (Massy) with a subsidiary in Montreal (Canada).

The strengths of the PhinC model are based on the following three pillars:

• Le Deep Learning: It consists in developing the best models to exploit all the research data at every phasein vitro, in vivo animal and human) and to carry out robust simulations and predictions that are acceptable for drug agencies (EMA, FDA, etc.).
• Agility and Biotech orientation: PhinC adapts its work organization and directs its collaborations to meet the needs and specificities of Biotech
• Expertise in drug development which allows PhinC to maintain a pragmatic approach to its modeling work to support the development objectives of the drug candidate.

If you have a strong desire to develop and apply modeling and simulation in drug development and enjoy collaborating with scientists from diverse backgrounds, then send us your CV and cover letter!